Translating basic neuroscience research into experimental neurology applications often requires functional interfacing of the central nervous system (CNS) with artificial devices designed to monitor and/or stimulate brain electrical activity. Ideally, such interfaces should provide a high temporal and spatial resolution over a large area of tissue during stimulation and/or recording of neuronal activity, with the ultimate goal to elicit/detect the electrical excitation at the single-cell level and to observe the emerging spatiotemporal correlations within a given functional area. Activity patterns generated by CNS neurons have been typically correlated with a sensory stimulus, a motor response, or a potentially cognitive process.
