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Highly focal BOLD activation on functional MRI in a patient with progressive myoclonic epilepsy and diffuse giant somatosensory evoked potentials.

MANGANOTTI, PAOLO
•
Brigo F.
•
Zoccatelli G.
altro
Bongiovanni L. G.
2011
  • journal article

Periodico
EPILEPSY & BEHAVIOR
Abstract
We analyzed the effect of afferent input on patterns of brain electrical activation in a 31-year-old man with progressive myoclonic epilepsy (PME) by measuring the somatosensory evoked potential (SSEP) amplitude at the scalp after median nerve stimulation and examining the changes in the functional magnetic resonance imaging blood oxygen level-dependent (fMRI BOLD) signal. High-amplitude SSEPs were elicited at the wrist in association with highly focal BOLD activation of the contralateral sensorimotor areas. By contrast, no diffuse activation of either the frontal or the posterior parietal cortical areas was observed, as seen in previously recorded data on SSEPs from a healthy control group. The highly focal BOLD activation in this patient suggests that cortex hyperexcitability might be limited to the sensorimotor cortex in PME. The combined EEG-fMRI findings highlight a dissociation between BOLD activation and neurophysiological findings.
DOI
10.1016/j.yebeh.2011.01.011
WOS
WOS:000288976100030
Archivio
http://hdl.handle.net/1234/2833072
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-79952734970
Diritti
metadata only access
Scopus© citazioni
4
Data di acquisizione
Jun 7, 2022
Vedi dettagli
Web of Science© citazioni
3
Data di acquisizione
Mar 21, 2024
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