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Cytoplasmic expression of oestrogen receptor beta (ERβ) as a prognostic factor in vulvar squamous cell carcinoma in elderly women
Zannoni G. F.
•
Prisco M. G.
•
Vellone V. G.
altro
Gallo D.
2011
journal article
Periodico
HISTOPATHOLOGY
Abstract
Aims: To investigate the prognostic value of cytoplasmic oestrogen receptor beta (ERβ) expression in a series of untreated patients with non-human papillomavirus (HPV)-related vulvar cancer. Methods and results: Immunohistochemistry was carried out using a polyclonal rabbit anti-human ERβ antibody. The nuclear and cytoplasmic expression of ERβ was evaluated in 33 patients. Cytoplasmic immunoreactivity was correlated with histopathological and molecular parameters (Ki67, p21), disease-free survival (DFS) and overall survival (OS). The expression of cytoplasmic ERβ was found to be associated with grade (P=0.006), while no association was found with any of the remaining variables examined. Cases with high cytoplasmic ERβ expression showed lower DFS and OS compared to cases with low cytoplasmic ERβ (P=0.007, P=0.01, respectively). There was also a progressive decline in both the DFS and OS with increasing tumour size (P=0.05, P=0.07, respectively) and with increasing depth of infiltration (P=0.14, P=0.07, respectively). On multivariate analysis, only tumour size and cytoplasmic ERβ staining retained an independent negative prognostic role for DFS and OS. Conclusions: The assessment of cytoplasmic ERβ expression could be helpful to identify poor prognosis in elderly patients with non-HPV-related vulvar squamous cell carcinoma (SCC). © 2011 Blackwell Publishing Limited.
DOI
10.1111/j.1365-2559.2011.04029.x
WOS
WOS:000297244900012
Archivio
https://hdl.handle.net/11390/1242527
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-81555214742
https://ricerca.unityfvg.it//handle/11390/1242527
Diritti
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Soggetti
Ki67
Oestrogen receptor be...
P21
Prognosi
Vulvar cancer
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