Of the 12 known carcinogenic HPV types, HPV16 is by far the most carcinogenic in terms of numbers of cases of cervical cancer and its immediate precursor, cervical intraepithelial neoplasia grade 3 (CIN3). HPV18 is second in terms of etiologic importance (but is disproportionately important for adenocarcinomas)(1-3).
Aims:Our study compares the risk of developing a CIN2+ lesions in women with HPV16 and 18, versus women with other HPV types. Sensitivity, specificity and their respective 95% confidence intervals (95%CI), positive predictive values (PPV) and negative predictive values (NPV) were also calculated on the basis of the results of cytologic and histologic follow-up.
