We consider hyperbolic 3-manifolds $M_{n}\left(k\right)$, which are
n-fold cyclic branched coverings of 2-bridge knots K. We show that
for n $\geq$ 5 the orientation-preserving isometry group of $M_{n}\left(k\right)$
either is a lift of a symmetry group of K or has a very special structure.
