This article aims to present the contents of this monographic issue and to expose some considerations on Italian-Yugoslav relations during the interwar period, in the frame-work of Italian strategies towards the Danube-Balkan region. For this purpose, some constants in the Italian eastwards projection and great power ambitions, between the last post-WWI liberal governments and the fascist regime, will be highlighted. Space will be dedicated to the role played by cultural circles and political propaganda, which represented crucial elements in order to support Italian hegemonic projects towards both Yugoslavia and the whole central and south-eastern European area.