Design and performance tests of the calorimetric tract of a Compton Camera for small-animals imaging

The bio-distribution and targeting capability of pharmaceuticals may be assessed in small animals by imaging gamma-rays emitted from radio-isotope markers. Detectors that exploit the Compton concept allow higher gamma-ray efficiency compared to conventional Anger cameras employing collimators, and feature sub-millimeter spatial resolution and compact geometry. We are developing a Compton Camera that has to address several requirements: the high rates typical of the Compton concept; detection of gamma-rays of different energies that may range from 140 key ((99m)Tc) to 511 keV (beta+ emitters); presence of gamma and beta radiation with energies up to 2 MeV in case of (188)Re. The camera consists of a thin position-sensitive Tracker that scatters the gamma ray, and a second position-sensitive detection system to totally absorb the energy of the scattered photons (Calorimeter). In this paper we present the design and discuss the realization of the calorimetric tract, including the choice of scintillator crystal, pixel size, and detector geometry. Simulations of the gamma-ray trajectories from source to detectors have helped to assess the accuracy of the system and decide on camera design. Crystals of different materials, such as LaBr(3) GSO and YAP, and of different size, in continuous or segmented geometry, have been optically coupled to a multi-anode Hamamatsu H8500 detector, allowing measurements of spatial resolution and efficiency. (C) 2010 Elsevier B.V. All rights reserved.