Terapie con estrogeni/ progestinici e corea di Sydenham: Riflessioni da una mapping review sulla prescrizione e sull’informazione ai pazienti [Estrogen/progestin therapies and Sydenham's chorea: a mapping review with reflections on prescribing and patient information]

Estrogen/progestin therapies (EPTs) have been associated with the development of chorea. Questions on this topic addressed to a patients’ association (the Sydenham’s Chorea Association, www.sydenhamschorea.com) prompted our mapping review of the literature (multiple databases, from the beginning to August 2024), from which emerged that Sydenham’s chorea (Sc) may represent an indicator of the risk of developing chorea with EPTs. This has stimulated a reflection on the use and need for balanced information on EPTs in people with a history of Sc. A more accurate detection of the phenomenon of chorea reactivation during the use of EPTs in persons with previous Sc and the identification of the most suitable therapeutic strategy (e.g. hormonal contraception) and the most appropriate time to discuss it with these patients would be of relevance in this regard.