Cystic fibrosis transmembrane conductance regulator modulates synaptic chloride homeostasis in motoneurons of the rat spinal cored during neonatal development

Cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-regulated Cl - channel functional in neonatal rat spinal motoneurons. The present study investigated the developmental (P1-P8) expression of CFTR, its impact on motoneuron excitability and Cl - homeostasis in relation to canonical Cl - transporters.