Background. Lyme Borreliosis is a multisystemic infection caused by spirochetes of Borrelia burgdorferi sensu lato complex.
The features of Lyme Borreliosis may differ in the various geographical areas, primarily between the manifestations found in
America and those found in Europe and Asia. Objective. to describe the clinical features of Lyme Borreliosis in an endemic
geographic area such as Friuli-Venezia Giulia in the Northeastern part of Italy. Methods.The medical records of patients resulted
seropositive for Borrelia burgdorferi have been retrospectively recorded and analyzed. Results. Seven hundred and five patients met
the inclusion criteria, 363 males and 342 females. Erythema migrans was the most common manifestation, detected in 437 patients.
Other classical cutaneous manifestations included 58 cases of multiple erythema migrans, 7 lymphadenosis benigna cutis, and 18
acrodermatitis chronica atrophicans. The musculoskeletal system was involved in 511 patients. Four hundred and sixty patients
presented a neurological involvement. Flu-like symptoms preceded or accompanied or were the only clinical feature in 119 patients.
Comments.The manifestations of Lyme borreliosis recorded in this study are similar to the ones of other endemic areas in Europe,
even if there are some peculiar features which are different from those reported in Northern Europe and in the USA.
