There is increasing evidence of cardiac involvement in COVID-19 cases, with a broad range
of clinical manifestations spanning from acute life-threatening conditions such as ventricular dysrhythmias, myocarditis, acute myocardial ischemia and pulmonary thromboembolism to long-term
cardiovascular sequelae. In particular, acute myocarditis represents an uncommon but frightening
complication of SARS-CoV-2 infection. Even if many reports of SARS CoV-2 myocarditis are present
in the literature, the majority of them lacks histological confirmation of cardiac injury. Here, we
report a case of a young lady, who died suddenly a few days after testing positive for SARS-CoV-2,
whose microscopic and genetics features suggested a direct cardiac involvement compatible with
fulminant myocarditis.
