Obesity has become one of the most common diseases in the world and represents a serious
public-health problem. The aim of this cross-sectional study was to examine the influence of dietary factors on
the association between two adiponectin SNPs and some biochemical parameters. Ninety-six, healthy nonsmoking
adults aged 25-49 participated in this cross sectional study. Two single nucleotide polymorphisms
(SNPs) at adiponectin (ADIPOQ) gene, +276G>T and +45T>G were genotyped in all participants. Additionally,
the participants underwent standard anthropomorphological measurements of body composition, blood
pressure measurements, dietary intake assessment and fasting serological measurements of glucose, insulin,
triacylglycerol’s, total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol, and
C-reactive protein. Based on measured biometrical parameters a statistical analysis was performed for assessing
dietary intake. The SNP276G<T and SNP45T<G of the ADIPOQ gene are associated with different responses of
total cholesterol, HDL cholesterol and C-reactive protein (CRP) to low or high intake of polyunsaturated fatty
acid, saturated fatty acid and omega-3 fatty acid.
