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Drug Release from Viscoelastic Swelling Polymeric Platforms

Ferreira, J. A.
•
de Oliveira, P.
•
Grassi, M.
•
Romanazzi, G.
2018
  • journal article

Periodico
SIAM JOURNAL ON APPLIED MATHEMATICS
Abstract
We consider a polymeric spherical platform containing a solid dispersed drug that is in contact with a solvent fluid. While swelling, a non-Fickian sorption of the solvent molecules occurs induced by the effect of the viscoelastic properties of the polymer. The solid drug in contact with the solvent fluid dissolves and a Fickian release of dissolved drug takes place. The fluid entrance, the drug dissolution, and the drug release to an external environment are described by a system of PDEs complemented with an equation for the swelling front, initial, and boundary conditions. The model includes the two major factors that govern a swelling process of a polymeric platform within a release medium: the cross-link density and the concentration of the external medium. Energy estimates for the mass of solvent fluid and of undissolved and dissolved drug in the polymeric platform are established. Numerical simulations that illustrate the theoretical results are also included.
DOI
10.1137/16M1100344
WOS
WOS:000437010200005
Archivio
http://hdl.handle.net/11368/2925978
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85049413763
https://epubs.siam.org/doi/pdf/10.1137/16M1100344
Diritti
open access
license:copyright editore
license:digital rights management non definito
FVG url
https://arts.units.it/request-item?handle=11368/2925978
Soggetti
  • drug release

  • viscoelastic platform...

  • swelling, mathematica...

  • qualitative behavior...

  • numerical simulation

Web of Science© citazioni
14
Data di acquisizione
Mar 27, 2024
Visualizzazioni
3
Data di acquisizione
Apr 19, 2024
Vedi dettagli
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