Breast cancer is thecmost frequency malignancy in women in the world and also in Italy.In Trieste most of breast lesions are investigated by fine needle aspiration cytology under ultrasound guidance (FNAC). Tru-cut is used when FNAC is inadequate, for discrepancy with radiology or to have a biomolecular profiling,expecially in neoadjuvant chemotherapy. Vacuum Aspiration Biopsy (VAB) is used in case of microcalcifications or mammographic abnormalitues without evidence of nodules.FNAC's goal is to define breast lesions avoiding more invasive procedures,, it provides several benefits for women, for pathologists and for the public health
