A 74-year-old Caucasian man with severe long-standing Palmoplantar pustular psoriasis (PPP) was treated with systemic therapy with efalizumab. Considerable improvement of PPP was observed after only 4 weeks of treatment and a complete recovery of daily activities was obtained after three months of therapy. A month later a sudden important
absence of side effects; adult; aged; blood testis barrier; case report; drug withdrawal; human; lab
reappearance of pustules were
noted. Systemic acitretin at an initial dose of 0.5 mg/kg/d
was started while continuing efalizumab. After 15 days an
almost complete disappearance of pustular lesions was reobserved. The dermatosis relapsed after suspension of the retinoid, despite ongoing efalizumab.
