A study focused on the application of passive seismic control strategies to the field of new prefab R/C structures is presented herein. A benchmark building was designed to the purpose, assuming the typical geometrical layout and dimensions of single-hall industrial buildings in Italy, which are also similar to the characteristics of the same class of buildings in other countries of the Mediterranean area. The design was carried out in the three following hypotheses: (a) according to a traditional ductility-based approach; (b) by incorporating dissipative bracings, equipped with fluid viscous dampers; (c) by placing a seismic isolation system at the base, composed of a set of double curved surface sliders. The earthquake and performance levels assumed, their relevant limitations, the design criteria and the technical installations of the three solution are discussed in detail. A comparison of relevant sizes, seismic performance and costs is finally presented.