Blue diode laser versus traditional infrared diode laser and quantic molecular resonance scalpel: Clinical and histological findings after excisional biopsy of benign oral lesions

This study aims to compare the use of the innovative blue diode laser (BLUE group) with two tradi- tional surgical techniques: the infrared diode laser (IR group) and the quantic molecular resonance scalpel (QMR group) in the excision of benign oral lesions. Ninety-three patients underwent surgical excision of a benign oral lesion and were followed up for 30 days for pain (0 to 10 visual analogue scale), bleeding, and painkillers’ assumption (yes/no). A blind pathologist evaluated the thermal damage along the cutting margin. Although referred pain was lowest in the BLUE group from day 7 on (p < 0.05), all patients referred minimum discomfort after surgery. The BLUE group reported minimum bleeding and necessity of sutures (p < 0.000). The QMR group showed the highest bleeding during surgery (p < 0.000), while after 14 and 30 days no patient bled. Most of the patients in all groups did not need painkillers. The lowest thermal damage (p < 0.000) was found in the BLUE group (71.3 ` 51.8 μm), whereas the IR group proved the highest (186.8 ` 82.7 μm) com- pared both with the BLUE and QMR (111.4 ` 55.4 μm) groups. All the techniques allowed correct histological sampling. All the experimented techniques offer interesting advantages, although the blue laser minimizes risk of bleeding with limited thermal damage.