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Targeting the pancreatic β-cell to treat diabetes

VETERE, AMEDEO
•
Choudhary, Amit
•
Burns, Sean M.
•
Wagner, Bridget K.
2014
  • journal article

Periodico
NATURE REVIEWS DRUG DISCOVERY
Abstract
Diabetes is a leading cause of morbidity and mortality worldwide, and predicted to affect over 500 million people by 2030. However, this growing burden of disease has not been met with a comparable expansion in therapeutic options. The appreciation of the pancreatic β-cell as a central player in the pathogenesis of both type 1 and type 2 diabetes has renewed focus on ways to improve glucose homeostasis by preserving, expanding and improving the function of this key cell type. Here, we provide an overview of the latest developments in this field, with an emphasis on the most promising strategies identified to date for treating diabetes by targeting the β-cell.
DOI
10.1038/nrd4231
WOS
WOS:000333906200023
Archivio
http://hdl.handle.net/11368/2845590
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84898598784
Diritti
closed access
license:creative commons
license uri:http://creativecommons.org/licenses/by-nd/3.0/it/
FVG url
https://arts.units.it/request-item?handle=11368/2845590
Soggetti
  • Animal

  • Blood Glucose

  • Diabetes Mellitus, Ty...

  • Diabetes Mellitus, Ty...

  • Drug Design

  • Human

  • Hypoglycemic Agent

  • Insulin-Secreting Cel...

  • Molecular Targeted Th...

  • Pharmacology

  • Drug Discovery3003 Ph...

Web of Science© citazioni
210
Data di acquisizione
Mar 15, 2024
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