Peptide bond synthesis was performed on PEGA beads under microwave radiations. Classical chemical coupling as well as
thermolysin catalyzed synthesis was studied, and the effect of microwave radiations on reaction kinetics, beads’ integrity, and
enzyme activity was assessed. Results demonstrate that microwave radiations can be profitably exploited to improve reaction
kinetics in solid phase peptide synthesis when both chemical and biocatalytic strategies are used.
