The synthesis and screening of neutral and cationic, linear and cyclic peptoids (N-alkylglycine peptidomimetics)
is described. Structure–activity relationship studies show that the in vitro activities of the tested
peptoids depend on both cyclization and decoration with cationic groups. The most powerful N-lysine
cyclopeptoid derivatives showed good antifungal activity against Candida albicans (ATCC90029 and
L21) and Candida famata (SA550, Amph B-resistant) and low hemolytic activity. The effects of the cyclic
peptoids on membrane permeabilization were evaluated by the propidium iodide exclusion assay.
