TEM-184, a Novel TEM-Derived Extended-Spectrum beta-Lactamase with Enhanced Activity against Aztreonam
Piccirilli A
•
Perilli M
•
Amicosante G
altro
Giani T
2018
Periodico
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Abstract
TEM-184, a novel TEM-derived extended-spectrum beta-lactamase (ESBL), was isolated from an Escherichia coli ST354 clinical strain. Compared to TEM-1, TEM-184 contains the mutations Q6K, E104K, I127V, R164S, and M182T. Kinetic analysis of this enzyme revealed extended-spectrum activity against aztreonam in particular. TEM-184 was also susceptible to inhibitors, including clavulanic acid, tazobactam, and avibactam.
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