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Autonomic dysfunction in post-COVID patients with and witfhout neurological symptoms: a prospective multidomain observational study

Buoite Stella, Alex
•
Furlanis, Giovanni
•
Frezza, Nicolò Arjuna
altro
Manganotti, Paolo
2022
  • journal article

Periodico
JOURNAL OF NEUROLOGY
Abstract
The autonomic nervous system (ANS) can be affected by COVID-19, and dysautonomia may be a possible complication in post-COVID individuals. Orthostatic hypotension (OH) and postural tachycardia syndrome (POTS) have been suggested to be common after SARS-CoV-2 infection, but other components of ANS function may be also impaired. The Composite Autonomic Symptom Scale 31 (COMPASS-31) questionnaire is a simple and validated tool to assess dysautonomic symptoms. The aim of the present study was to administer the COMPASS-31 questionnaire to a sample of post-COVID patients with and without neurological complaints. Participants were recruited among the post-COVID ambulatory services for follow-up evaluation between 4 weeks and 9 months from COVID-19 symptoms onset. Participants were asked to complete the COMPASS-31 questionnaire referring to the period after COVID-19 disease. Heart rate and blood pressure were manually taken during an active stand test for OH and POTS diagnosis. One-hundred and eighty participants were included in the analysis (70.6% females, 51 ± 13 years), and OH was found in 13.8% of the subjects. Median COMPASS-31 score was 17.6 (6.9–31.4), with the most affected domains being orthostatic intolerance, sudomotor, gastrointestinal and pupillomotor dysfunction. A higher COMPASS-31 score was found in those with neurological symptoms (p < 0.01), due to more severe orthostatic intolerance symptoms (p < 0.01), although gastrointestinal (p < 0.01), urinary (p < 0.01), and pupillomotor (p < 0.01) domains were more represented in the non-neurological symptoms group. This study confirms the importance of monitoring ANS symptoms as a possible complication of COVID-19 disease that may persist in the post-acute period.
DOI
10.1007/s00415-021-10735-y
WOS
WOS:000684472700001
Archivio
http://hdl.handle.net/11368/2993618
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85112366834
https://link.springer.com/article/10.1007/s00415-021-10735-y
Diritti
open access
FVG url
https://arts.units.it/bitstream/11368/2993618/4/BuoiteStella2022_AutonomicLongCOVID.pdf
Soggetti
  • COVID-19

  • long-COVID

  • Autonomic dysfunction...

  • COMPASS-31

  • Orthostatic intoleran...

Scopus© citazioni
12
Data di acquisizione
Jun 7, 2022
Vedi dettagli
Web of Science© citazioni
82
Data di acquisizione
Mar 25, 2024
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