A numerical investigation is carried out on the effects of flow maldistribution on the temperature uniformity and overall ther-mal resistance in double-layered microchannel heat sinks. Dif-ferent flow maldistribution models accounting for the effects of some typical header designs are considered together with differ-ent combinations of the average inlet velocity in the two layers of microchannels for a given total mass flow rate. The numerical simulations are carried out using an in-house FEM procedure previously developed by the authors for the analysis of cross-flow microchannel heat exchangers.