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RELATIONSHIP BETWEEN SEBOSTATIC ACTIVITY, TOLLERABILITY AND EFFICAY OF THREE TOPICAL DRUGS TO TREAT MILD TO MODERATE ACNE

STINCO, Giuseppe
•
PATRONE, Pasquale
•
Bragadin G
altro
Pillon B
2007
  • journal article

Periodico
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
Abstract
Background: Acne is a multifactorial disorder in which the sebum plays an important pathogenetic role. Purpose of the study: To evaluate the sebostatic effect of three anti-acneic ingredients (azelaic acid, adapalene and benzoyl peroxide) conveyed in cream and to determine whether there is a correlation with the therapeutic results. Materials and methods: Sixty-five patients with mild or moderate acne localized on the face were divided into three therapy groups at random: 25 applied azelaic acid once a day, 20, benzoyl peroxide and 20, adapalene. All the patients were observed at the time of enrolling and a further four times at fortnightly intervals. At each visit the sebum casual level on the forehead, chin and one cheek was measured using a sebumeter. Furthermore, side-effects and clinical-therapeutic effectiveness were noted. Results: Four patients did not complete the study. Azelaic acid showed an average reduction of 13.9% in sebum production on the forehead, 14.2% on the chin and 15.2% on the cheek. Benzoyl peroxide caused an increase of 10.5% in sebum production on the forehead, 10.3% on the chin and 25.4% on the cheek. Adapalene reduced sebaceous secretion by 0.2% on the forehead and 6.7% on the cheek whereas sebum production increased by 6.2% on the chin. All three drugs showed a clinical improvement in the acneic lesions with moderate adverse effects. Conclusion: The three topical drugs bring about good therapeutic results with scarce side-effects that do not, however, seem to be correlated with the sebostatic activity. © 2006 European Academy of Dermatology and Venereology.
DOI
10.1111/j.1468-3083.2006.01914.x
WOS
WOS:000244244200004
Archivio
http://hdl.handle.net/11390/881694
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-33846980450
Diritti
closed access
Scopus© citazioni
50
Data di acquisizione
Jun 14, 2022
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Web of Science© citazioni
34
Data di acquisizione
Mar 21, 2024
Visualizzazioni
2
Data di acquisizione
Apr 19, 2024
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