Pd-loaded Ce0. 6Zr0. 4O2 supported on Al2O3 are investigated as catalysts for the reduction of NO by CO. The attention is focused on the role of the support and of the Pd dispersion on the catalytic activity. The system shows a very high activity below 500 K which is almost independent on the Pd dispersion. The high activity is attributed to a promoting effect of the Ce0. 6Zr0. 4O2 on the NO conversion.