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Multicenter research into the quality of life of patients with advanced oropharyngeal carcinoma with long-term survival associated with human papilloma virus

SPINATO, GIACOMO
•
Stellin, Marco
•
Azzarello, Giuseppe
altro
TIRELLI, GIAN CARLO
2017
  • journal article

Periodico
ONCOLOGY LETTERS
Abstract
The treatment of advanced-stage oropharyngeal squamous cell carcinoma may utilize various modes, including combining surgery with chemoradiotherapy (CTRT), or primary CTRT followed by rescue surgery. In previous literature it has been revealed how patients treated with combined modes report a low quality of life (QoL) and severe consequences following surgery, radiotherapy and chemotherapy, in the short and in the long-term. The decrease in the QoL of patients treated with high-intensity multi-modal strategies highlights the necessity of modifying treatments, particularly for young HPV-positive patients, where an increased survival rate has already been reported. The modified treatment for HPV-positive tumors in the tonsils and at the base of the tongue is based on the deintensification of therapies aiming to reduce toxicity and thereby improve QoL in the long term, whilst still maintaining therapeutic effectiveness. The aim of the present study was to evaluate the QoL in patients with a long-term survival, who were treated with combined therapy for squamous cell tumors in the tonsils and at the base of the tongue, and to compare the results observed in HPV-positive and HPV-negative patients. According to statistical analysis, differences in the general QoL and in the single scales of the European Organization for the Research and Treatment of Cancer questionnaires were not correlated with the type of therapy selected for the particular patient. QoL considered the presence of HPV, the type of treatment, the subregion of the tonsils vs. the base of the tongue and the disease stage at the time of diagnosis, and was determined to be non-influential with regard to these specific variables.
DOI
10.3892/ol.2017.6152
WOS
WOS:000405645700026
Archivio
http://hdl.handle.net/11368/2909057
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85020215976
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494809/
Diritti
open access
FVG url
https://arts.units.it/bitstream/11368/2909057/1/multicenter research into the qol of patoents with advanced oropharyngeal k with long term survival associated with hpv.pdf
Soggetti
  • Deintensification the...

  • Human papillomaviru

  • Oropharyngeal carcino...

  • Quality of life

  • Radiochemotherapy

  • Oncology

  • Cancer Research

Scopus© citazioni
8
Data di acquisizione
Jun 14, 2022
Vedi dettagli
Web of Science© citazioni
8
Data di acquisizione
Mar 28, 2024
Visualizzazioni
2
Data di acquisizione
Apr 19, 2024
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