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Minimal residual disease after transplantation or lenalidomide-based consolidation in myeloma patients: a prospective analysis

Oliva, S
•
Gambella, M
•
Gilestro, M
altro
PATRIARCA, Francesca
2017
  • journal article

Periodico
ONCOTARGET
Abstract
We analyzed 50 patients who achieved at least a very good partial response in the RV-MM-EMN-441 study. Patients received consolidation with autologous stem-cell transplantation (ASCT) or cyclophosphamide-lenalidomide-dexamethasone (CRD), followed by Lenalidomide-based maintenance. We assessed minimal residual disease (MRD) by multi-parameter flow cytometry (MFC) and allelic-specific oligonucleotide real-time quantitative polymerase chain reaction (ASO-RQ-PCR) after consolidation, after 3 and 6 courses of maintenance, and thereafter every 6 months until progression. By MFC analysis, 19/50 patients achieved complete response (CR) after consolidation, and 7 additional patients during maintenance. A molecular marker was identified in 25/50 patients, 4/25 achieved molecular-CR after consolidation, and 3 additional patients during maintenance. A lower MRD value by MFC was found in ASCT patients compared with CRD patients (p = 0.0134). Tumor burden reduction was different in patients with high-risk vs standard-risk cytogenetics (3.4 vs 5.2, ln-MFC; 3 vs 6 ln-PCR, respectively) and in patients who relapsed vs those who did not (4 vs 5, ln-MFC; 4.4 vs 7.8 ln-PCR). MRD progression anticipated clinical relapse by a median of 9 months while biochemical relapse by a median of 4 months. MRD allows the identification of a low-risk group, independently of response, and a better characterization of the activity of treatments.
DOI
10.18632/oncotarget.12641
WOS
WOS:000393289000044
Archivio
http://hdl.handle.net/11390/1107667
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85010818822
Diritti
open access
Scopus© citazioni
26
Data di acquisizione
Jun 14, 2022
Vedi dettagli
Web of Science© citazioni
28
Data di acquisizione
Mar 18, 2024
Visualizzazioni
1
Data di acquisizione
Apr 19, 2024
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