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The elementary events underlying force generation in neuronal lamellipodia

Amin, L
•
Ercolini, E
•
Shahapure, R
altro
Torre, V.
2011
  • journal article

Periodico
SCIENTIFIC REPORTS
Abstract
We have used optical tweezers to identify the elementary events underlying force generation in neuronal lamellipodia. When an optically trapped bead seals on the lamellipodium membrane, Brownian fluctuations decrease revealing the underlying elementary events. The distribution of bead velocities has long tails with frequent large positive and negative values associated to forward and backward jumps occurring in 0.1-0.2 ms with varying amplitudes up to 20 nm. Jump frequency and amplitude are reduced when actin turnover is slowed down by the addition of 25 nM Jasplakinolide. When myosin II is inhibited by the addition of 20 mu M Blebbistatin, jump frequency is reduced but to a lesser extent than by Jasplainolide. These jumps constitute the elementary events underlying force generation.
DOI
10.1038/srep00153
WOS
WOS:000300556400001
SCOPUS
2-s2.0-84859776117
Archivio
http://hdl.handle.net/20.500.11767/16974
Diritti
open access
Soggetti
  • Settore BIO/09 - Fisi...

Web of Science© citazioni
11
Data di acquisizione
Jun 5, 2022
Scopus© citazioni
11
Data di acquisizione
Jun 7, 2022
Vedi dettagli
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