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MBL2 gene polymorphisms are correlated with high-risk human papillomavirus infection but not with human papillomavirus-related cervical cancer.

SEGAT, LUDOVICA
•
CROVELLA, SERGIO
•
COMAR, Manola
altro
CAMPELLO, CESARE
2009
  • journal article

Periodico
HUMAN IMMUNOLOGY
Abstract
We investigated whether there is a correlation between MBL2 polymorphisms and the host susceptibility to human papillomavirus (HPV) infection and cancer development. Toward this end, we analyzed MBL2 exon 1 polymorphisms in 172 women infected by strains of HPV that are associated with high-risk of cervical cancer development (or "high-risk" HPV infection), 105 of whom had HPV-related squamous cell carcinoma of the cervix (SCC), as well as 105 women not infected by HPV. We demonstrated an association of MBL2 polymorphisms with high-risk HPV infection in women without SCC who showed increased presence of the mutant MBL2 0 allele and 0/0 genotype as compared with women with SCC and healthy controls. No correlation with MBL2 polymorphisms was found in women who developed cancer. Therefore we propose that MBL2 polymorphisms responsible for defective production of mannose binding lectin (MBL) protein play a role in the increased susceptibility to high-risk HPV infection but not to cervical cancer onset and development.
DOI
10.1016/j.humimm.2009.03.006
WOS
WOS:000266806900011
Archivio
http://hdl.handle.net/11368/2262599
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-67349139917
Diritti
metadata only access
Soggetti
  • MBL2, High-risk HPV, ...

Web of Science© citazioni
16
Data di acquisizione
Mar 25, 2024
Visualizzazioni
1
Data di acquisizione
Apr 19, 2024
Vedi dettagli
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