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Proline-rich antimicrobial peptides targeting protein synthesis

Graf, Michael
•
Mardirossian, Mario
•
Nguyen, Fabian
altro
Wilson, Daniel N.
2017
  • journal article

Periodico
NATURAL PRODUCT REPORTS
Abstract
The innate immune system employs a broad array of antimicrobial peptides (AMPs) to attack invading microorganisms. While most AMPs act by permeabilizing the bacterial membrane, specific subclasses of AMPs have been identified that pass through membranes and inhibit bacterial growth by targeting fundamental intracellular processes. One such subclass is the proline-rich antimicrobial peptides (PrAMPs) that bind to the ribosome and interfere with the process of protein synthesis. A diverse range of PrAMPs have been identified in insects, such as bees, wasps and beetles, and crustaceans, such as crabs, as well as in mammals, such as cows, sheep, goats and pigs. Mechanistically, the best-characterized PrAMPs are the insect oncocins, such as Onc112, and bovine bactenecins, such as Bac7. Biochemical and structural studies have revealed that these PrAMPs bind within the ribosomal exit tunnel with a reverse orientation compared to a nascent polypeptide chain. The PrAMPs allow initiation but prevent the transition into the elongation phase of translation. Insight into the interactions of PrAMPs with their ribosomal target provides the opportunity to further develop these peptides as novel antimicrobial agents.
DOI
10.1039/c7np00020k
WOS
WOS:000404847900004
Archivio
http://hdl.handle.net/11368/2921856
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85022183754
http://pubs.rsc.org/en/Content/ArticleLanding/2017/NP/C7NP00020K
Diritti
open access
FVG url
https://arts.units.it/request-item?handle=11368/2921856
Soggetti
  • Animal

  • Anti-Bacterial Agent

  • Anti-Infective Agent

  • Antimicrobial Cationi...

  • Cattle

  • Coleoptera

  • Microbial Sensitivity...

  • Peptide

  • Peptides, Cyclic

  • Proline

  • Sheep

  • Swine

  • Wasp

  • Biochemistry

  • Drug Discovery3003 Ph...

  • Organic Chemistry

Scopus© citazioni
88
Data di acquisizione
Jun 14, 2022
Vedi dettagli
Web of Science© citazioni
121
Data di acquisizione
Mar 11, 2024
Visualizzazioni
1
Data di acquisizione
Apr 19, 2024
Vedi dettagli
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