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Polysaccharide-Based Networks from Homogeneous Chitosan-Tripolyphosphate Hydrogels: Synthesis and Characterization

SACCO, PASQUALE
•
BORGOGNA, MASSIMILIANO ANTONIO
•
TRAVAN, Andrea
altro
DONATI, IVAN
2014
  • journal article

Periodico
BIOMACROMOLECULES
Abstract
Polysaccharide networks, in the form of hydrogels and dried membranes based on chitosan and on the cross-linker tripolyphosphate (TPP), were developed using a novel approach. TPP was incorporated into chitosan by slow diffusion to favor a controlled gelation. By varying chitosan, TPP, and NaCl concentration, transition from inhomogeneous to homogeneous systems was achieved. Rheology and uniaxial compression tests enabled to identify the best performing hydrogel composition with respect to mechanical properties. FTIR, (31)P NMR, and spectrophotometric methods were used to investigate the interaction chitosan-TPP, the kinetics of phosphates diffusion during the dialysis and the amount of TPP in the hydrogel. A freeze-drying procedure enabled the preparation of soft pliable membranes. The lactate dehydrogenase assay demonstrated the biocompatibility of the membranes toward fibroblasts. Overall, we devised a novel approach to prepare homogeneous macroscopic chitosan/TPP-based biomaterials with tunable mechanical properties and good biocompatibility that show good potential as novel polysaccharide derivatives
DOI
10.1021/bm500909n
WOS
WOS:000341409800021
Archivio
http://hdl.handle.net/11368/2806123
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84907494364
Diritti
metadata only access
Soggetti
  • IONIC CROSS-LINKING

  • CONTROLLED-RELEASE

  • BIOMEDICAL APPLICATIO...

  • NANOPARTICLES

  • DELIVERY

  • CHONDROCYTE

  • STABILITY

  • GENIPIN

  • FORMULATIONS

  • MICROGELS

Web of Science© citazioni
69
Data di acquisizione
Mar 27, 2024
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