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Covalent Decoration of Cortical Membranes with Graphene Oxide as a Substrate for Dental Pulp Stem Cells

Roberta Di Carlo
•
Susi Zara
•
Alessia Ventrella
altro
Antonella Fontana
2019
  • journal article

Periodico
NANOMATERIALS
Abstract
(1) Background: The aim of this study was to optimize, through a cheap and facile protocol, the covalent functionalization of graphene oxide (GO)-decorated cortical membrane (Lamina®) in order to promote the adhesion, the growth and the osteogenic differentiation of DPSCs (Dental Pulp Stem Cells); (2) Methods: GO-coated Laminas were fully characterized by Scannsion Electron Microscopy (SEM) and Atomic Force Microscopy (AFM) analyses. In vitro analyses of viability, membrane integrity and calcium phosphate deposition were performed; (3) Results: The GO-decorated Laminas demonstrated an increase in the roughness of Laminas, a reduction in toxicity and did not affect membrane integrity of DPSCs; and (4) Conclusions: The GO covalent functionalization of Laminas was effective and relatively easy to obtain. The homogeneous GO coating obtained favored the proliferation rate of DPSCs and the deposition of calcium phosphate.
DOI
10.3390/nano9040604
WOS
WOS:000467768800120
Archivio
http://hdl.handle.net/11368/2957959
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85065301341
https://www.mdpi.com/2079-4991/9/4/604
Diritti
open access
FVG url
https://arts.units.it/bitstream/11368/2957959/1/Nanomaterials9(2019)604.pdf
Soggetti
  • graphene oxide

  • covalent functionaliz...

  • cortical membrane

  • calcium phosphate dep...

Web of Science© citazioni
16
Data di acquisizione
Mar 27, 2024
Visualizzazioni
6
Data di acquisizione
Apr 19, 2024
Vedi dettagli
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