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Tissue-tracking in the assessment of late gadolinium enhancement in myocarditis and myocardial infarction

Doimo S.
•
Ricci F.
•
Aung N.
altro
Petersen S. E.
2020
  • journal article

Periodico
MAGNETIC RESONANCE IMAGING
Abstract
Purpose: To test the diagnostic performance of cardiovascular magnetic resonance (CMR) tissue-tracking (TT) to detect the presence of late gadolinium enhancement (LGE) in patients with a diagnosis of myocardial infarction (MI) or myocarditis (MYO), preserved left ventricular ejection fraction (LVEF) and no visual regional wall motion abnormalities (RWMA). Methods: We selected consecutive CMR studies of 50 MI, 50 MYO and 96 controls. Receiving operating characteristic (ROC) curve and net reclassification index (NRI) analyses were used to assess the predictive ability and the incremental diagnostic yield of 2D and 3D TT-derived strain parameters for the detection of LGE and to measure the best cut-off values of strain parameters. Results: Overall, cases showed significantly reduced 2D global longitudinal strain (2D-GLS) values compared with controls (−20.1 ± 3.1% vs −21.6 ± 2.7%; p = 0.0008). 2D-GLS was also significantly reduced in MYO patients compared with healthy controls (−19.7 ± 2.9% vs −21.9 ± 2.4%; p = 0.0001). 3D global radial strain (3D-GRS) was significantly reduced in MI patients compared with controls with risk factors (34.3 ± 11.8% vs 40.3 ± 12.5%, p = 0.024) Overall, 2D-GLS yielded good diagnostic accuracy for the detection of LGE in the MYO subgroup (AUROC 0.79; NRI (95% CI) = 0.6 (0.3, 1.02) p = 0.0004), with incremental predictive value beyond risk factors and LV function parameters (p for AUROC difference = 0.048). In the MI subgroup, 2D-GRS (AUROC 0.81; NRI (95% CI) = 0.56 (0.17, 0.95) p = 0.004), 3D-GRS (AUROC 0.82; NRI (95% CI) = 0.57 (0.17, 0.97) p = 0.006) and 3D global circumferential strain (3D-GCS) (AUROC 0.81; NRI (95% CI) = 0.62 (0.22, 1.01) p = 0.002) emerged as potential markers of disease. The best cut-off for 2D-GLS was −21.1%, for 2D- and 3D-GRS were 39.1% and 37.7%, respectively, and for 3D-GCS was −16.4%. Conclusions: At CMR-tissue tracking analysis, 2D-GLS was a significant predictor of LGE in patients with myocarditis but preserved LVEF and no visual RWMA. Both 2D- and 3D-GRS and 2D-GCS yielded good diagnostic accuracy for LGE detection in patients with previous MI but preserved LVEF and no visual RWMA.
DOI
10.1016/j.mri.2020.08.008
WOS
WOS:000576737000008
Archivio
http://hdl.handle.net/11368/2994940
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85089848131
https://www.sciencedirect.com/science/article/pii/S0730725X20300424
Diritti
closed access
FVG url
https://arts.units.it/request-item?handle=11368/2994940
Soggetti
  • Female

  • Human

  • Image Processing, Com...

  • Male

  • Middle Aged

  • Myocardial Infarction...

  • Myocarditi

  • Predictive Value of T...

  • ROC Curve

  • Reproducibility of Re...

  • Stroke Volume

  • Contrast Media

  • Gadolinium

  • Magnetic Resonance Im...

Web of Science© citazioni
1
Data di acquisizione
Mar 28, 2024
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