Logo del repository
  1. Home
 
Opzioni

Meta-analysis and time series modeling allow a systematic review of primary HIV-1 drug-resistant prevalence in Latin America and Caribbean

Coelho, Antonio Victor Campos
•
De Moura, Ronald Rodrigues
•
Da Silva, Ronaldo Celerino
altro
Crovella, Sergio
2015
  • journal article

Periodico
CURRENT HIV RESEARCH
Abstract
Here we review the prevalence of HIV-1 primary drug resistance in Latin America and Caribbean using meta-analysis as well as time-series modeling. We also discuss whether there could be a drawback to HIV/AIDS programs due to drug resistance in Latin America and Caribbean in the next years. We observed that, although some studies report low or moderate primary drug resistance prevalence in Caribbean countries, this evidence needs to be updated. In other countries, such as Brazil and Argentina, the prevalence of drug resistance appears to be rising. Mutations conferring resistance against reverse transcriptase inhibitors were the most frequent in the analyzed populations (70% of all mutational events). HIV-1 subtype B was the most prevalent in Latin America and the Caribbean, although subtype C and B/F recombinants have significant contributions in Argentina and Brazil. Thus, we suggest that primary drug resistance in Latin America and the Caribbean could have been underestimated. Clinical monitoring should be improved to offer better therapy, reducing the risk for HIV-1 resistance emergence and spread, principally in vulnerable populations, such as men who have sex with men transmission group, sex workers and intravenous drug users.
DOI
10.2174/1570162x13999150317155040
WOS
WOS:000353283700005
Archivio
http://hdl.handle.net/11368/2964343
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84930983012
http://www.eurekaselect.com/129585/article
Diritti
open access
FVG url
https://arts.units.it/request-item?handle=11368/2964343
Soggetti
  • Drug resistance mutat...

  • HAART

  • primary drug resistan...

  • meta-analysi

  • systematic review

  • time serie

  • Anti-HIV Agent

  • Antiretroviral Therap...

  • Caribbean Region

  • Drug Resistance, Vira...

  • HIV Infection

  • HIV-1

  • Human

  • Latin America

  • Mutation

  • Prevalence

  • Sex Workers

Web of Science© citazioni
1
Data di acquisizione
Mar 9, 2024
google-scholar
Get Involved!
  • Source Code
  • Documentation
  • Slack Channel
Make it your own

DSpace-CRIS can be extensively configured to meet your needs. Decide which information need to be collected and available with fine-grained security. Start updating the theme to match your nstitution's web identity.

Need professional help?

The original creators of DSpace-CRIS at 4Science can take your project to the next level, get in touch!

Realizzato con Software DSpace-CRIS - Estensione mantenuta e ottimizzata da 4Science

  • Impostazioni dei cookie
  • Informativa sulla privacy
  • Accordo con l'utente finale
  • Invia il tuo Feedback