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Differential induction of IL-17, IL-10, and IL-9 in human T helper cells by B7h and B7.1

Mesturini, Riccardo
•
Gigliotti, Casimiro L.
•
Orilieri, Elisabetta
altro
DIANZANI, Umberto
2013
  • journal article

Periodico
CYTOKINE
Abstract
ICOS and CD28 are expressed by T cells and are involved in costimulation of cytokine production in T helper (TH) cells. ICOS binds B7h expressed by several cell types, whereas CD28 binds B7.1 and B7.2 expressed by activated antigen presenting cells. This work investigated the role of B7h and B7.1 in TH17 and TH9 cell differentiation by assessing activity of recombinant B7h-Fc and B7.1-Fc on human naïve TH cells activated in the presence of different combinations of exogenous cytokines. In the presence of TGF-β1 and IL-1β (TH17 promoting condition), B7h-Fc was more effective than B7.1-Fc in inducing IL-17A and IL-10 secretion, whereas B7.1-Fc was more effective in inducing IL-17F. Dual costimulation with B7h-Fc and B7.1-Fc displayed an intermediate pattern with predominance of IL-17F over IL-17A, secretion of high levels of IL-10, and secretion of IL-9 levels lower than those induced by B7.1-Fc alone. In the presence of TGF-β1 and IL-4 (TH9 promoting condition), B7h-Fc induced IL-17A only, whereas B7.1-Fc induced also IL-17F, IL-10, and high levels of IL-9. Experiments on memory TH cells showed that B7h-Fc mainly supported secretion of IL-17A and IL-10, whereas B7.1-Fc supported secretion of IL-17A, IL-17F, IL-10, and IL-9. These data indicate that B7h and B7.1 play different roles in modulation of TH17 and TH9 differentiation. This plasticity might be important in the immune response to pathogens and tumors, and in the development of autoimmune diseases, and should be taken in consideration in designing of immunotherapeutic protocols triggering ICOS or CD28.
DOI
10.1016/j.cyto.2013.05.021
WOS
WOS:000325442700047
Archivio
http://hdl.handle.net/11368/2855880
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84883551505
Diritti
metadata only access
Soggetti
  • CD28 IL-17

  • ICOS

  • IL-9

  • TH17

  • TH9

  • Antigens, CD28

  • Antigens, CD80

  • Cell Differentiation

  • Human

  • Inducible T-Cell Co-S...

  • Inducible T-Cell Co-S...

  • Interleukin-10

  • Interleukin-17

  • Interleukin-1beta

  • Interleukin-9

  • Leukocytes, Mononucle...

  • Lymphocyte Activation...

  • Recombinant Protein

  • T-Lymphocytes, Helper...

  • Th17 Cell

  • Transforming Growth F...

  • Immunology

  • Immunology and Allerg...

  • Hematology

  • Biochemistry

  • Molecular Biology

Scopus© citazioni
15
Data di acquisizione
Jun 14, 2022
Vedi dettagli
Web of Science© citazioni
17
Data di acquisizione
Mar 21, 2024
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