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Antiemetic prophylaxis in patients undergoing hematopoietic stem cell transplantation: a multicenter survey of the Gruppo Italiano Trapianto Midollo Osseo (GITMO) transplant programs

Pastore D.
•
Bruno B.
•
Carluccio P.
altro
Bonifazi F.
2020
  • journal article

Periodico
ANNALS OF HEMATOLOGY
Abstract
A survey within hematopoietic stem cell transplant (HSCT) centers of the Gruppo Italiano Trapianto Midollo Osseo (GITMO) was performed in order to describe current antiemetic prophylaxis in patients undergoing HSCT. The multicenter survey was performed by a questionnaire, covering the main areas on chemotherapy-induced nausea and vomiting (CINV): antiemetic prophylaxis guidelines used, antiemetic prophylaxis in different conditioning regimens, and methods of CINV evaluation. The survey was carried out in November 2016, and it was repeated 6 months after the publication of the Multinational Association of Supportive Care in Cancer (MASCC)/European Society for Medical Oncology (ESMO) specific guidelines on antiemetic prophylaxis in HSCT. The results show a remarkable heterogeneity of prophylaxis among the various centers and a significant difference between the guidelines and the clinical practice. In the main conditioning regimens, the combination of a serotonin3 receptor antagonist (5-HT3-RA) with dexamethasone and neurokin1 receptor antagonist (NK1-RA), as recommended by MASCC/ESMO guidelines, increased from 0 to 15% (before the publication of the guidelines) to 9–30% (after the publication of the guidelines). This study shows a lack of compliance with specific antiemetic guidelines, resulting mainly in under-prophylaxis. Concerted strategies are required to improve the current CINV prophylaxis, to draft shared common guidelines, and to increase the knowledge and the adherence to the current recommendations for CINV prophylaxis in the specific field of HSCT.
DOI
10.1007/s00277-020-03945-3
WOS
WOS:000515975100002
Archivio
http://hdl.handle.net/11390/1176846
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85079444783
link.springer.de/link/service/journals/00277/index.htm
Diritti
metadata only access
Soggetti
  • Antiemetic prophylaxi...

  • CINV

  • Hematopoietic stem ce...

  • MASCC/ESMO guidelines...

Scopus© citazioni
4
Data di acquisizione
Jun 14, 2022
Vedi dettagli
Web of Science© citazioni
7
Data di acquisizione
Mar 24, 2024
Visualizzazioni
2
Data di acquisizione
Apr 19, 2024
Vedi dettagli
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