Overthe past half-century, there have been many advances in the design, construction, and implantation of joint prostheses, resulting in a high percentage of successful long-term outcomes. One of the most common concerns of both patients and physicians is the problem of joint replacements becoming loose over time. Causes of failure include infections, aseptic loosening, dislocations, and fracture of the prosthesis or bone. Multidisciplinary research team studies are needed for an improvement in understanding in pathophysiological mechanisms of joint implant loosening and failure, which is the key point to improve implant survival and to minimize revisions.
