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A systems-oriented analysis of the grapevine R2R3-MYB transcription factor family uncovers new insights into the regulation of stilbene accumulation

Wong, Darren Chern Jan
•
Schlechter, Rudolf
•
Vannozzi, Alessandro
altro
CASTELLARIN, Simone Diego
2016
  • journal article

Periodico
DNA RESEARCH
Abstract
R2R3-MYB transcription factors (TFs) belong to a large and functionally diverse protein superfamily in plants. In this study, we explore the evolution and function of this family in grapevine (Vitis vinifera L.), a high-value fruit crop. We identified and manually curated 134 genes using RNA-Seq data, and named them systematically according to the Super-Nomenclature Committee. We identified novel genes, splicing variants and grapevine/woody-specific duplicated subgroups, suggesting possible neo- and sub-functionalization events. Regulatory network analysis ascribed biological functions to uncharacterized genes and validated those of known genes (e.g. secondary cell wall biogenesis and flavonoid biosynthesis). A comprehensive analysis of different MYB binding motifs in the promoters of co-expressed genes predicted grape R2R3-MYB binding preferences and supported evidence for putative downstream targets. Enrichment of cis-regulatory motifs for diverse TFs reinforced the notion of transcriptional coordination and interaction between MYBs and other regulators. Analysis of the network of Subgroup 2 showed that the resveratrol-related VviMYB14 and VviMYB15 share common co-expressed STILBENE SYNTHASE genes with the uncharacterized VviMYB13. These regulators have distinct expression patterns within organs and in response to biotic and abiotic stresses, suggesting a pivotal role of VviMYB13 in regulating stilbene accumulation in vegetative tissues and under biotic stress conditions.
DOI
10.1093/dnares/dsw028
WOS
WOS:000386964800004
Archivio
http://hdl.handle.net/11390/1114685
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84991769821
http://dnaresearch.oxfordjournals.org/
https://academic.oup.com/dnaresearch/article-lookup/doi/10.1093/dnares/dsw028
Diritti
open access
Soggetti
  • Cell wall

  • Radiation

  • Ripening

  • Stre

  • Wine

  • Medicine (all)

  • Molecular Biology

  • Genetics

Scopus© citazioni
81
Data di acquisizione
Jun 14, 2022
Vedi dettagli
Web of Science© citazioni
88
Data di acquisizione
Mar 28, 2024
Visualizzazioni
2
Data di acquisizione
Apr 19, 2024
Vedi dettagli
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