Bioinspired artificial proteins modelled on tropoelastin represent an attractive tool for many biotechnological and biomedical applications. In this work, a recombinant Human Elastin-like Polypeptide (HELP) comprising the most regularly repeated hexapeptidic motif of human tropoelastin, has been employed to prepare HELP-based or –coated biomaterials. In vitro characterization of the polypeptide based materials was aimed to evaluate their potential application for blood vessel reconstruction.