The Openness trait is a core dimension in the Big-Five model of personality. The relationship between Openness and creativity is discussed regarding creative potential versus achievement, self-assessed versus others-assessed measures, and implications for creative self-beliefs. Underlying mechanisms that justify the relationship between Openness and creativity are reported, including cognitive, cerebral, emotional, and motivational mechanisms. Socio-cultural implications on personality traits and creativity are taken into consideration, including aspects related to individualist versus collectivist cultures, as well as domain generality across fields of artists and scientists. The entry concludes with a discussion of Leonardo da Vinci, a prime example of Openness.