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Incidence and progression to cirrhosis of new hepatitis C virus infections in persons living with human immunodeficiency virus

Puoti, M. a
•
Lorenzini, P. b
•
Cozzi Lepri
altro
BASSETTI, MATTEO
2016
  • journal article

Periodico
CLINICAL MICROBIOLOGY AND INFECTION
Abstract
Objective: To estimate the incidence of hepatitis C virus (HCV) seroconversion and the risk of severe fibrosis/cirrhosis in HCV seroconverters among persons with human immunodeficiency virus (HIV) infection. Methods: We analysed data on 4059 persons with HIV enrolled in a cohort study in Italy. Results: Incidence rate of seroconversion was 0.6/100 person-years overall, and drug users and menwho-have-sex-with-men were at highest risk. The cumulative risk of progression to severe fibrosis/cirrhosis was 30% by 10 years after seroconversion. Conclusions: New HCV infections have a rapidly progressive course in this population. Persons with HIV and HCV superinfection should be prioritized for treatment with anti-HCV direct-acting antivirals.
DOI
10.1016/j.cmi.2016.12.003
WOS
WOS:000400295300014
Archivio
http://hdl.handle.net/11390/1112486
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85009179815
http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1469-0691
Diritti
metadata only access
Soggetti
  • Cirrhosi

  • Cohort study

  • Hepatitis C viru

  • Human immunodeficienc...

  • Incidence

  • Microbiology (medical...

  • Infectious Diseases

Web of Science© citazioni
8
Data di acquisizione
Mar 26, 2024
Visualizzazioni
6
Data di acquisizione
Apr 19, 2024
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