VDR polymorphisms influence immunological response in HIV-1+ individuals undergoing antiretroviral therapy
da Silva R. C.
•
Alves N. M. P.
•
Pereira J. J. S.
altro
Silva J. A.
2019
Periodico
GENETICS AND MOLECULAR BIOLOGY
Abstract
Vitamin D exerts an immuno-modulatory activity on several immune system cells through the vitamin D receptor (VDR). Herein, we verified that age and a therapeutic regimen containing protease inhibitors are associated with failures in antiretroviral therapies (ARVs). In addition, we assessed whether a VDR SNP (rs11568820: C allele and CC genotype) and GC (rs2228570-rs11568820) allelic combinations are associated with immunological failure (p < 0.05). Our findings suggest a possible role of VDR SNPs on immunological failure in HIV-1+ individuals undergoing regular ARVs.
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open access
license:creative commons
license uri:http://creativecommons.org/licenses/by/4.0/
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