Glass windows and facades are very popular in buildings, both in the form of traditional partitions and novel adaptive skins. There, given a series of intrinsic material features, special care should be spent at the design stage, so as to ensure appropriate fail-safe requirements, especially in presence of extreme design loads such as impacts. Even more attention is required for complex glass assemblies such as Triple Glass Units (TGUs), where the interaction of multiple components (i.e. the glass layers and the bonding foils, with the framing members) as well as the presence of gas cavities can further affect the dynamic response of these sys-tems. In this paper, major outcomes of a research project in progress for the per-formance assessment of TGU windows under explosive loading are reported.