New alkylacetamide derivatives as new sigma ligands.

On the basis of some substituted benzylacetamide derivatives previously synthesized by us [1] and gifted with excellent activity toward sigma1 receptor subtype (best sigma1Ki= 0,09 nM), we synthesized a new series (1 a-o) of alkylacetamide derivatives in order to establish the influence of an alkyl chain, rather than an aryl moiety, on sigma1 receptor affinity of the corresponding compounds and their selectivity over sigma2 receptor subtype.