The authors analyze the clinical aspects of HIV infection in light of the most recent studies. The natural history of the disease appears more definite than in the recent years, but many aspects are still unclear. Current therapy and future therapeutic trends are also discussed. A prospective study of 108 HIV-positive subjects, observed for periods ranging from 6 months to 2 years showed a cumulative probability of evolution to full-blown AIDS of 34.4%/year for subjects with immunodeficiency (WR3-WR5 groups, according to the Walter Reed classification). Finally, the authors report their clinical experience with 35 patients with full-blown AIDS from 1984 to 1987.
