A convenient chemoenzymatic synthesis of (R)-(-) and (S)-(+)-homo-beta-proline

Both enantiomers of the heterocyclic GABA analogue homo-b-proline (3-pyrrolidineacetic acid) were synthesized by a chemoenzymatic method involving the use of two enantiocomplementary enzymes in the disymmetric hydrolyses of 3-nitromethylglutaric acid diethyl ester