SMEs’ willingness to adopt Open Innovation largely depends on managerial cognitive configurations. The present study inquiries a scarcely explored aspect of Open Innovation (OI), namely the human side of OI. As a result, we study the cognitive configurations leading toward willingness or unwillingness of OI adoption, specifically focusing on the cognitive side of the decision-makers. In doing so, we explore the role of Rational and Intuitive cognition, together with the NIH and NHS syndromes. Also, we study the effect of perceived barriers and perceived benefits that are able to affect the decisional outcome of managers in deciding to adopt OI. The present is grounded in a survey among 442 qualified and experienced managers working in SMEs. Results of a fsQCA analysis outlines different decisional profiles associated with willingness to adopt OI.