Design, synthesis and SAR analysis of novel selective sigma1 ligands (Part 2)

In order to investigate the molecular features involved in sigma receptors (r-Rs) binding, new compounds based on arylalkylaminoalcoholic, arylalkenyl- and arylalkylaminic scaffolds were synthesized and their affinity towards r1- and r2-Rs subtypes was evaluated. The most promising compounds were also screened for their affinity at l-opioid, d-opioid and j-opioid receptors. Biological results are herein presented and discussed.