We study some semi-linear equations for the (m, p)-Laplacian operator on locally finite weighted graphs. We prove existence of weak solutions for all m is an element of N and p is an element of (1,+infinity) via a variational method already known in the literature by exploiting the continuity properties of the energy functionals involved. When m = 1, we also establish a uniqueness result in the spirit of the Brezis- Strauss Theorem. We finally provide some applications of our main results by dealing with some Yamabe-type and Kazdan-Warner-type equations on locally finite weighted graphs.