Following the relationship between subjectivity and knowledge from Empirisme et subjectivité (1953) to Differénce et repetition (1968), this article gives an account of Hume’s influence on the «transcendental empiricism» which is, according to the most part of recent deleuzian studies, the fundamental theoretical spectrum of Deleuze’s thought. The author shows, in this way, how Deleuze methodically reads Hume to create an «heretical» version of Kant’s transcendental philosophy.